- Ph.D., University of New Mexico, Alberquerque
- M.S., Sichuan University
- B.S., Sichuan University
- Associate Professor, Chemistry
- Mount Marty College
a) The long term goal of this project is to develop novel antibiotics that are less prone to bacterial resistance. The hypothesis is that a class of central metabolic enzymes such as MRSA acetate kinase (ACK), MRSA fructose bisphosphate aldolase (FBPA), MRSA phosphotransacetylase (PTA), Mannitol-1-phosphate 5-dehydrogenase (M1P5D) and MRSA HPr kinase/phosphorylase (HprK/P), which are in. silico. essential to bacterial growth and absent in humans, are promising drug targets. The importance of this project lies in the fact that the proposed research sheds light on a brand new class of MRSA antibiotics, which paves the road to multi-faceted approaches to combat antibiotic resistance.
b) This project aims to investigate the role of Epstein-Barr virus, Streptococcus pneumonia and Acinetobacter baumannii in the pathogenesis of multiple sclerosis. Previous study reviewed that segments of myelin proteins (MOG, PLP, and MBP) injected into mice induce Experimental autoimmune encephalomyelitis (EAE). Does human disease mimic this process due to introduction of myelin-mimicking proteins from Epstein-Barr virus (EBV) and/or Streptococcus pneumoniae (S. pneumonia) and/or Acinetobacter baumannii (A. baumannii). Does disease type/severity depend upon the introduction of particular microorganisms? Does the disease progress in a particular order after initiation of disease according to introduction of particular agent?