- Postdoctoral Research Associate, School of Medicine & Dentistry, University of Rochester, N.Y.
- Ph.D., Toxicology, University of Rochester, N.Y.
- B.S., Biology, Lafayette College, Easton, Penn.
- Associate Scientist, Sanford Research/USD
Toxins in our environment cause human disease by disrupting normal cellular and physiological processes. The Vitiello laboratory works to identify and define the molecular interface between environmental toxins and biological systems, influencing tissue development, homeostasis, and disease pathogenesis. Research is targeted at understanding how atmospheric chemicals alter redox signaling and molecular networks via cysteine oxidation. Furthermore, a major emphasis is placed on thioredoxin and glutathione systems in the biochemical regulation of cysteine oxidation during oxidative injury. We are specifically interested in the physiological relevance of these molecular pathways in the pulmonary epithelium, an important cellular barrier and sensor of atmospheric toxins, including oxygen transitioning during birth and therapeutic administration of excess oxygen (hyperoxia) in pre-term babies. Students working in the laboratory are expected to make original research contributions after receiving training on experimental design, instrument operation, and data analysis applying molecular approaches across cellular and animal systems.