Carrie Olson-Manning, Ph.D.
- Assistant Professor, Biology
- Augustana University
- Post-doc, Protein Evolution, University of Chicago, Chicago, IL
- Ph.D., Evolutionary Genetics, Duke University, Durham, NC
- B.S., Evolution and Genetics, University of Minnesota, Minneapolis/St. Paul, MN
Current Research: Corticosteroids are a class of important steroid hormones that regulate stress response (cortisol) and salt balance (aldosterone) in tetrapods. In most mammals, a single enzyme (CYP11B) is responsible for making these hormones. Whether CYP11B preferentially produces aldosterone or cortisol is determined by allosterically regulation by another enzyme, CYP11A1. My lab studies the interaction of CYP11B and CYP11A across the mammalian tree to determine the genetic and biochemical mechanisms of allosteric regulation of the corticosteroid pathway in mammals.