Cecelia Miles, Ph.D.
- Assistant Professor, Biology
- Augustana University
- NRSA Postdoctoral Fellow, NIH Kirschstein, University of Chicago
- Ph.D., Zoology, University of Florida, Gainsville
- M.S., Biological Sciences, Florida Institute of Technology, Melbourne
- B.S., Marine Biology, Texas A&M University, College Station
In previous work we used inbred inbred lines of Drosophila melanogaster artificially selected for large- and small-egg size to examine the architecture of developing ovaries (organogenesis). We also used whole-genome sequencing to identify candidate genes associated with egg size in the base populations from which these inbred lines were derived (Jha et al., 2015). We intend to extend this work to examine multiple life history traits using inbred fly lines (derived from these same base populations) that have undergone long term laboratory adaptation to cold temperatures (16.5°C). It is well documented that flies raised at these colder temperatures produce larger eggs relative to controls. But, shifts in reproductive investment are often accompanied by trade-offs in other life history traits. We intend to examine several of these traits including egg size, egg number, body size, and larval development time. This information is necessary to design appropriate experiments to examine whether these cold-adapted flies utilize the same pathways that we previously identified in their directly selected cousins. Are they building their large eggs in the same way as the directly selected flies, or have priorities changed? What is the cost of producing larger eggs at these temperatures?