Carrie Olson-Manning, Ph.D.
- Assistant Professor, Biology
- Augustana University
- Post-doc, Protein Evolution, University of Chicago, Chicago, IL
- Ph.D., Evolutionary Genetics, Duke University, Durham, NC
- B.S., Evolution and Genetics, University of Minnesota, Minneapolis/St. Paul, MN
My lab is broadly focused on understanding evolution in metabolic pathways. We have two systems that we are currently studying to understand pathways. 1) Corticosteroids are a class of important steroid hormones that regulate stress response (cortisol) and salt balance (aldosterone) in tetrapods. In most mammals, a single enzyme (CYP11B) is responsible for making these hormones. Whether CYP11B preferentially produces aldosterone or cortisol is determined by allosterically regulation by another enzyme, CYP11A1. My lab studies the interaction of CYP11B and CYP11A across the mammalian tree to determine the genetic and biochemical mechanisms of allosteric regulation of the corticosteroid pathway in mammals. 2) This summer we will establish a system in two species of milkweed that will allow us to address questions, including: what is the biochemical and genetic basis of species differences in Asclepias speciosa and A. syriaca, are species differences reinforced in hybrid zones, what alleles move between species and are these alleles important for adaptive traits. Students will be offered training opportunities in ecological field research, molecular biology, genomics, and bioinformatics.